Table 7. In Vivo Pharmacokinetic Parameters of Various 5-FU Formulations Following Transdermal Application on Rat Skin (Mean ± Standard)a.
| pharmacokinetic parameters | drug-sol | EL3-S60 | EL3-S80 | EL3-T80 | EL3-S80 gel |
|---|---|---|---|---|---|
| Cmax (μg/mL) | 65.56 ± 2.4 | 140.09 ± 4.5 | 328.70 ± 7.3 | 110.05 ± 4.7 | 133.56 ± 2.4 |
| Tmax (h) | 4.3 | 12.1 | 12.4 | 8.2 | 8.1 |
| AUC0–∞ (μg h/mL) | 78.77 ± 2.1 | 125.44 ± 5.1 | 166.32 ± 3.7 | 146.18 ± 3.2 | 153.21 ± 3.1 |
| AUMC (μg h2/mL) | 724.15 ± 7.5 | 1174.42 ± 12.3 | 1578.53 ± 11.5 | 1243.44 ± 8.3 | 1365.91 ± 12.1 |
| MRT (h) | 9.19 | 9.36 | 9.49 | 8.51 | 8.91 |
| T1/2 (h) | 5.78 | 13.86 | 23.1 | 17.32 | 34.64 |
| Ke (h–1) | 0.12 ± 0.02 | 0.05 ± 0.01 | 0.03 ± 0.02 | 0.04 ± 0.03 | 0.02 ± 0.03 |
a
AUC = area under the curve, AUMC = area under first moment curve, Ke = elimination rate constant, MRT = mean residence time.