Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Small molecule screen identifies ZnF-UBD hits. (A) Heat map showing binding of 64 ligands to 11 ZnF-UBDs by SPR. A 4-fold 6-point dilution series beginning at 200 μM was used for KD determination with N = 1. (B) Summary of binding data for compound 59 by SPR, N ≥ 3. (C) Representative SPR binding curve from steady-state fit analysis and sensorgrams for USP3 ZnF-UBD and 59. A KD of 14 ± 4 μM was obtained from the average of seven independent measurements.
