Table 1.

Three-independent variable, five-level CCD and experimental data for response variables.

Coded and real variable levels				Tested bioactivities in percentage (%)
Run	Factor 1 S.hispanica (mg/ml)	Factor 2 C.quinoa (mg/ml)	Factor 3 N.nucifera (mg/ml)	Response 1 pancreatic α-amylase inhibition	Response 2 α-glucosidase inhibition	Response 3 Lipase inhibition	Response 4 DPPH Scavenging	Response 5 ABTS●+ Scavenging
1	1.68179 (2.34)	0 (1.5)	0 (1.5)	51.34	55.55	53.89	72.52	66.52
2	−1 (1)	1 (2)	−1 (1)	59.45	61.93	51.46	61.75	55.75
3	0 (1.5)	0 (1.5)	0 (1.5)	72.29	71.87	60.49	72.67	63.56
4	0 (1.5)	0 (1.5)	−1.68179 (0.65)	50.30	54.20	52.49	62.47	51.77
5	−1 (1)	−1 (1)	−1 (1)	33.58	62.61	57.58	56.40	48.95
6	1 (2)	1 (2)	1 (2)	49.65	55.89	53.52	71.51	63.20
7	0 (1.5)	0 (1.5)	0 (1.5)	74.73	70.49	57.58	70.86	65.29
8	0 (1.5)	1.68179 (2.34)	0 (1.5)	58.46	60.17	52.43	68.84	59.94
9	0 (1.5)	0 (1.5)	0 (1.5)	75.07	71.25	59.75	72.67	62.11
10	0 (1.5)	0 (1.5)	1.68179 (2.34)	48.06	62.69	52.43	71.51	55.82
11	0 (1.5)	−1.68179 (0.65)	0 (1.5)	41.54	60.24	56.32	64.50	44.32
12	0 (1.5)	0 (1.5)	0 (1.5)	76.57	73.62	60.26	69.63	66.38
13	1 (2)	−1 (1)	−1 (1)	46.67	57.95	58.95	67.32	45.99
14	1 (2)	1 (2)	−1 (1)	52.79	54.43	52.72	64.86	51.63
15	−1.68179 (0.65)	0 (1.5)	0 (1.5)	42.19	66.36	50.49	62.26	47.14
16	−1 (1)	−1 (1)	1 (2)	30.55	61.31	54.2	64.64	43.17
17	1 (2)	−1 (1)	1 (2)	48.96	56.27	56.15	68.26	51.48
18	0 (1.5)	0 (1.5)	0 (1.5)	71.39	71.64	60.26	70.86	64.14
19	−1 (1)	1 (2)	1 (2)	39.75	61.31	50.94	68.35	53.43
20	0 (1.5)	0 (1.5)	0 (1.5)	73.73	73.39	59.86	71.66	67.39

∗α = 1.68179 (star or axial point for CCD in the case of three independent variables).

∗Numbers in bracket denotes the concentration of seed extracts (mg/ml) in each run.

Seed combination of polyherbal formulation showing maximum bioactivities has been highlighted.