TABLE 2.
Final model estimation parameters and bootstrap analysis.
| Parameter | Final model | Bootstrap analysis | |
|---|---|---|---|
| Estimate [RSE (%)] | Median estimate [RSE (%)] | 95%CI | |
| CL (L/h) | 1.05 (17.2) | 1.07 (18.7) | 0.721–1.53 |
| V (L) | 69.0 (6.61) | 68.6 (6.87) | 59.9–77.7 |
| θUV-CL | 1.90 (16.5) | 1.91 (18.4) | 1.31–2.71 |
| Intre-individual variability | |||
| ω (%) for CL | 12.1 (47.9) | 11.5 (45.0) | 2.45–22.0 |
| Residual variability | |||
| σ (%) | 9.78 (29.1) | 9.60 (28.4) | 4.70–15.2 |
The success rate was calculated as 100% (1000/1000).
The final model was as follows: CL (L/h)=1.05*1.90LOG(UV+10)/2.3, V (L) = 69.0.
Intre-individual variability for V was not estimated.
Abbreviations: CL, typical apparent clearance; V, typical apparent volume distribution; θUV-CL, 24-h urine volume as a covariate for CL; ω, interindividual variance for CL; σ, residual variability for proportional error; RSE, residual standard error; CI, confidence interval.