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. 2024 Jan 12;29:12. doi: 10.1186/s11658-023-00530-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Serum eccDNA SORBS1^circle level is increased in newly diagnosed T2DM patients. A Visualization of the most significantly upregulated serum eccDNA SORBS1^circle. The junction site of eccDNA SORBS1^circle was TCTG. B Gel electrophoresis images of validated serum eccDNA SORBS1^circle. C qPCR validation of serum eccDNA SORBS1^circle level in serum obtained from 106 newly diagnosed T2DM patients and 40 NC subjects. **P < 0.01. D ROC curves for the capacity of the serum eccDNA SORBS1^circle to differentiate T2DM patients from NC subjects