Table 2.
Clinical outcomes at 90 days and 1 year
| SHR levels | Frequencies | Crude Model | Model 1a | Model 2b | Model 3c | ||||
|---|---|---|---|---|---|---|---|---|---|
| Unadjusted OR (95% CI) | P value | Adjusted OR (95% CI) | P value | Adjusted OR (95% CI) | P value | Adjusted OR (95% CI) | P value | ||
| 90 days | |||||||||
| mRS score of 0–3, No. (%) | |||||||||
| T1 (≤ 1.11) | 48 (57.8) | Reference | Reference | Reference | Reference | ||||
| T2 (1.12–1.36) | 24 (28.9) | 0.30 (0.16–0.57) | < 0.001 | 0.26 (0.12–0.56) | 0.001 | 0.25 (0.11–0.55) | 0.001 | 0.25 (0.11–0.56) | 0.001 |
| T3 (≥ 1.37) | 29 (34.5) | 0.38 (0.21–0.72) | 0.003 | 0.37 (0.18–0.80) | 0.01 | 0.37 (0.17–0.80) | 0.01 | 0.33 (0.15–0.74) | 0.007 |
| P for trend | 0.004 | 0.01 | 0.01 | 0.01 | |||||
| mRS score at 90 days, median (IQR)* | |||||||||
| T1 (≤ 1.11) | 3 (1–6) | Reference | Reference | Reference | Reference | ||||
| T2 (1.12–1.36) | 5 (2–6) | 0.42 (0.24–0.72) | 0.002 | 0.45 (0.26–0.79) | 0.006 | 0.44 (0.25–0.79) | 0.006 | 0.45 (0.25–0.82) | 0.009 |
| T3 (≥ 1.37) | 5 (2–6) | 0.44 (0.25–0.76) | 0.003 | 0.54 (0.31–0.96) | 0.04 | 0.57 (0.32–1.01) | 0.054 | 0.45 (0.25–0.82) | 0.009 |
| P for trend | 0.005 | 0.046 | 0.07 | 0.01 | |||||
| Mortality, No. (%) | |||||||||
| T1 (≤ 1.11) | 22 (26.5) | Reference | Reference | Reference | Reference | ||||
| T2 (1.12–1.36) | 33 (39.8) | 1.83 (0.95–3.53) | 0.07 | 1.68 (0.82–3.44) | 0.15 | 1.81 (0.87–3.75) | 0.11 | 1.89 (0.83–4.32) | 0.13 |
| T3 (≥ 1.37) | 34 (40.5) | 1.89 (0.98–3.63) | 0.06 | 1.59 (0.78–3.25) | 0.20 | 1.54 (0.74–3.17) | 0.25 | 2.14 (0.95–4.83) | 0.07 |
| P for trend | 0.07 | 0.24 | 0.30 | 0.08 | |||||
| 1 year | |||||||||
| mRS score of 0–3, No. (%) | |||||||||
| T1 (≤ 1.11) | 46 (59.0) | Reference | Reference | Reference | Reference | ||||
| T2 (1.12–1.36) | 27 (34.6) | 0.37 (0.19–0.71) | 0.003 | 0.34 (0.16–0.73) | 0.006 | 0.36 (0.16–0.77) | 0.009 | 0.37 (0.17–0.85) | 0.02 |
| T3 (≥ 1.37) | 28 (35.9) | 0.39 (0.20–0.74) | 0.004 | 0.38 (0.18–0.82) | 0.01 | 0.41 (0.19–0.88) | 0.02 | 0.37 (0.16–0.82) | 0.02 |
| P for trend | 0.006 | 0.02 | 0.03 | 0.02 | |||||
| mRS score at 1 year, median (IQR)† | |||||||||
| T1 (≤ 1.11) | 3 (0–6) | Reference | Reference | Reference | Reference | ||||
| T2 (1.12–1.36) | 6 (2–6) | 0.41 (0.23–0.73) | 0.003 | 0.44 (0.24–0.81) | 0.009 | 0.45 (0.24–0.84) | 0.01 | 0.49 (0.26–0.93) | 0.03 |
| T3 (≥ 1.37) | 5 (2–6) | 0.46 (0.26–0.82) | 0.008 | 0.60 (0.33–1.10) | 0.10 | 0.63 (0.34–1.17) | 0.14 | 0.53 (0.28–1.00) | 0.05 |
| P for trend | 0.01 | 0.12 | 0.17 | 0.06 | |||||
| Mortality, No. (%) | |||||||||
| T1 (≤ 1.11) | 27 (34.6) | Reference | Reference | Reference | Reference | ||||
| T2 (1.12–1.36) | 41 (52.6) | 2.09 (1.10–3.99) | 0.03 | 1.95 (0.97–3.93) | 0.06 | 1.84 (0.90–3.75) | 0.09 | 1.75 (0.80–3.81) | 0.16 |
| T3 (≥ 1.37) | 38 (48.7) | 1.79 (0.94–3.42) | 0.08 | 1.52 (0.76–3.05) | 0.24 | 1.42 (0.70–2.88) | 0.34 | 1.73 (0.80–3.73) | 0.16 |
| P for trend | 0.10 | 0.29 | 0.39 | 0.19 | |||||
Abbreviations: mRS Modified Rankin Scale, SHR Stress hyperglycemia ratio, OR Odds ratio, CI Confidence interval
*P value for odds propotional assumption was 0.28 for mRS score at 90 days
†P value for odds propotional assumption was 0.20 for mRS score at 1 year
aModel 1 adjusted for age, baseline NIHSS, stroke etiology and occlusion site
bModel 2 adjusted for covariates from Model 1and further adjusted for history of diabetes mellitus and intravenous thrombolysis status
cModel 3 adjusted for covariates from Model 2 and further adjusted for sex and successful recanalization