Fig. 1.

Identification of DEGs and screening of hub genes. A The volcanic plots of DEGs analysis in GSE135838, GSE57193, and GSE41919 datasets. B The Venn diagram shows 29 DEGs at the intersection of three datasets. C, D Cluster dendrograms. In terms of dynamic tree cut, the genes from GSE135838 and GSE57193 were clustered into different modules through hierarchical clustering. Diverse colors indicate respective different modules. E, F The associations between clinical traits and modules, in which red represents a higher correlation coefficient. GSE57193 involves a Turquoise module containing 622 genes (r = 0.857, P<0.001), whereas GSE135838 involves a Green module containing 110 genes (r = 0.521, P<0.01). G The Venn diagram shows the seven hub genes that overlap 29 DEGs, Turquoise module genes, and Green module genes