Table 1.

In vitro and in vivo studies have proved the therapeutic potential of exosomes in amelioration of skin photoaging

Exosome source	Cargo	Signaling pathway	Study model	Ref
HucMSC	14–3-3ζ	SIRT1 pathway	HaCaT cells, Rat model of acute photodamage	[74]
ADSCs	miR-1246, lncRNA H19	Nrf2, MAPK/AP-1, TGF-β/Smad	HSF cells, Kunming mice UVB-irradiated mice	[75, 76]
BM-MSCs	miR-29b-3p	MAPK/AP-1	HDF cells	[77]
iPSCs	N/A	TGF-β	HDF cells	[78]
HDF	miRNA-22-5p, miR-133a, miR-223	MAPK, TGF-β/Smad	HDF monolayer and spheroids, nude mouse model	[79, 80]
HUVEC	N/A	Cell proliferation, collagen synthesis	HDF	[81]
Fungi extract	miR-CM1	Mical2-inuced aging	HaCaT, Kunming mice	[82]