Table 3.
Diagnostic accuracy of the proposed criteria in classifying prodromal FTD from healthy controls
| AUC (95% CI) | Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|---|
| Whole group (n = 398) | |||||
| Core criteria | 0.79 (0.73–0.84) | 56.5% | 92.8% | 76.5% | 83.8% |
| Plasma NfLa | 0.68 (0.59–0.77) | 63.0% | 66.1% | 40.3% | 83.2% |
| Anterior cingulateb | 0.69 (0.62–0.77) | 55.1% | 77.6% | 42.7% | 85.1% |
| Core criteria + NfLa | 0.84 (0.76–0.91) | 69.6% | 86.4% | 65.3% | 88.5% |
| Core criteria + anterior cingulateb | 0.82 (0.76–0.89) | 64.7% | 90.6% | 67.7% | 89.4% |
| Core criteria + NfL + anterior cingulatea | 0.90 (0.82–0.97) | 81.8% | 93.0% | 77.1% | 94.7% |
| EYO < 5 years (n = 139) | |||||
| Core criteria | 0.85 (0.78–0.93) | 80.0% | 87.4% | 78.4% | 88.4% |
| Plasma NfLc | 0.65 (0.49–0.81) | 60.0% | 69.7% | 47.4% | 79.3% |
| Anterior cingulated | 0.72 (0.61–0.83) | 45.2% | 89.2% | 66.7% | 77.3% |
| Core criteria + NfLc | 0.92 (0.83–1.00) | 80.0% | 93.9% | 85.7% | 91.2% |
| Core criteria + anterior cingulated | 0.92 (0.86–0.98) | 83.3% | 87.5% | 75.8% | 91.8% |
| Core criteria + NfL + anterior cingulatec | 0.97 (0.93–1.00) | 91.7% | 96.4% | 91.7% | 96.4% |
MCBMI Mild cognitive and/or behavior and/or motor impairment, AUC Area under the curve, PPV Positive predictive value, NPV Negative predictive value, NfL Neurofilament light, EYO Estimated years to onset
an = 173
bn = 297
cn = 48
dn = 96