FIG. 3.
Influence of OHHL and OdDHL on TNF-α and IL-12 production by LPS-stimulated adherent murine peritoneal macrophages. (a) OdDHL inhibited TNF-α release at 3.35 × 10−5 M. OHHL did not inhibit the production of TNF-α. CT, control level of TNF-α release. (b) OdDHL also inhibited IL-12 production by LPS-stimulated macrophages at all concentrations tested. DMSO at equivalent concentrations to those in AHL-containing samples had no effect on the assay (data not shown). Error bars indicate standard deviations. +ve, positive control (no OdDHL added). ∗∗, P < 0.01.