FIG. 4.
Influence of OHHL and OdDHL on specific antibody production in the KAP model of a secondary antibody response. OdDHL inhibited the production of specific antibody by antigen-stimulated KLH-primed murine spleen cells at a concentration of 8 × 10−5 M (P < 0.01). Antibody production was significantly enhanced at lower concentrations of the compound. ∗, P < 0.05; ∗∗, P < 0.01. Error bars indicate standard deviations. The value of 1 represents the positive control level (CT). DMSO at equivalent concentrations to those in AHL-containing samples had no effect on the assay (data not shown).