Table 7. Toxicity Profiles of (3) Predicted Using ProTox-II.

classification	Target	prediction	probability
organ toxicity	hepatotoxicity	active	0.50
toxicity endpoints	carcinogenicity	active	0.52
toxicity endpoints	immunotoxicity	inactive	0.99
toxicity endpoints	mutagenicity	active	0.65
toxicity end points	cytotoxicity	inactive	0.73
Tox21-nuclear receptor signaling pathways	AhR	active	0.61
Tox21-nuclear receptor signaling pathways	androgen receptor	inactive	0.98
Tox21-nuclear receptor signaling pathways	androgen receptor ligand binding domain (AR-LBD)	inactive	0.96
Tox21-nuclear receptor signaling pathways	aromatase	inactive	0.76
Tox21-nuclear receptor signaling pathways	estrogen receptor alpha	inactive	0.78
Tox21-nuclear receptor signaling pathways	estrogen receptor ligand binding domain	inactive	0.99
Tox21-nuclear receptor signaling pathways	peroxisome proliferator activated-receptor gamma (PPAR-Gamma)	inactive	0.94
Tox21-stress response pathways	nuclear factor (erythroid-derived 2)-like 2/antioxidant responsive element (nrf2/ARE)	inactive	0.86
Tox21-stress response pathways	heat shock factor response element	inactive	0.86
Tox21-stress response pathways	mitochondrial membrane potential	inactive	0.70
Tox21-stress response pathways	phosphoprotein (tumor suppressor) p53	inactive	0.76
Tox21-stress response pathways	ATPase family AAA domain-containing protein 5 (ATAD5)	inactive	0.69