Table 2.
Topic names. Names were assigned based on their top diagnostic codes (Supplementary Fig. 1 and Supplementary Table 3 for the full list of selected diagnostic codes).
There were 24,860 TBI patients and 38,284 control patients who were assigned TSi = 0 where i = 1, 2,…,19 due to not being diagnosed with any of the 314 selected diagnostic codes during their pre-injury phase. For the remainder of the patients, topic scores were computed for all 19 topics as per Equation (1), which were extremely positively skewed for each group, with the highest range being 0.0368 to 2796.025 for TBI-Validation set (Table 3 for statistics). Topic scores were then rank-normalized within each group of the split sets. The normalized topic scores, from here on referred to as Topici where i = 1, 2,…, 19, were then used along with socio-demographic variables (age at injury, sex, rurality indicator, income quintile) for prediction tasks.
| Topic | Name |
|---|---|
| Topic 1 | Heart disorders and symptoms |
| Topic 2 | Microbial and allergic skin, eye, and upper airway manifestations |
| Topic 3 | Stroke and excessive involuntary movement disorders |
| Topic 4 | Kidney failure, sepsis, anemia |
| Topic 5 | Injuries to extremities, disorders of musculoskeletal system, overexertion |
| Topic 6 | Respiratory disorders, obstruction, and symptoms |
| Topic 7 | Infectious/inflammatory diseases of skin and urinary system, and related concerns |
| Topic 8 | Arthritis and manifestations of inflammatory, traumatic, and autoimmune disorders |
| Topic 9 | Disorders of sense organs, trauma of upper extremities, and nutritional deficiencies |
| Topic 10 | Inflammatory, traumatic multisystem disorders and mental manifestations |
| Topic 11 | Lesions in anorectal area, venous and skin insufficiencies |
| Topic 12 | General symptoms, migraine, and diseases of central nervous system |
| Topic 13 | Unspecified back, depressive, and other diseases |
| Topic 14 | Newborn/infant care and ill-defined infections |
| Topic 15 | Unspecified anxiety, neurotic, and associated states |
| Topic 16 | Symptoms of digestive, nervous, musculoskeletal, and excretion systems |
| Topic 17 | Drug dependence and addiction |
| Topic 18 | Unknown causes of morbidity and mortality |
| Topic 19 | Disorders of glucose intolerance and complications |