Table 3. B Cell-Related Enriched Processes, Biomarkers, and Diseases Associated with Multiple PFAS Exposures Identified by GSEA.

cluster	name	overlapping genes	p value	hit type
B cell receptor signaling	CD72 → AP-1 expression targets	MAP2K4; E2F5; CDCA4; MAP2K3	0.0007	biomarkers
	B cell receptor → NFATC signaling	CD19; IGHM	0.0175	signal processing
	B cell receptor → NF-κB signaling	CD19; IGHM	0.0295	signal processing
	B cell receptor → AP-1 signaling	CD19; IGHM	0.0449	signal processing
TLR signaling	TLR4 → AP-1 expression targets	LDLR; MAP2K3; MAP2K4	0.0177	biomarkers
	TLR → AP-1 signaling	MAP2K4; MAP2K3	0.0191	signal processing
T cell–B cell interaction	T cell-dependent B cell activation	RASGRP3; MAP2K3; IGHM	0.0277	biological process
	MHC2-mediated antigen presentation	HLA-DMA; IFI30	0.0313	biological process
E2A signaling	NOTCH → TCF3 signaling	MAP2K4; MAP2K3; TCF3	0.0002	signal processing
	Hodgkin and Reed–Sternberg cell reprogramming	POU2F2; EBF1; TCF3	0.0014	disease