Figure 1: Schematic of the HS aided proton walk algorithm.

During the transformation, the potential is set such that the two interchanging residues are both uncharged, while having the high free energy of solvation of the charged state, and the Lennard-Jones are set to half of those of the fully grown atom. Spheres represent amino acids, colored in black for uncharged moieties, blue for charged moities, and pink for moieties that are in the alternative potential state used for charge transfer in the auxilary Markov chain.