FIG. 1.

IL-12 activity in BALF and lung homogenates of A/J mice inoculated intratracheally with L. pneumophila. A/J mice were inoculated intratracheally with L. pneumophila as described in Materials and Methods. At specific time points thereafter, the mice were sacrificed and IL-12 was assessed in BALF (A) and whole lung homogenates (B) by ELISA. Results represent the means ± standard errors of the means for three to five animals per time point, ∗, significantly greater than value for uninfected mice (i.e., 125 pg of IL-12 per ml of BALF; 935 pg of IL-12 per lung) (analysis of variance, P < 0.05).