Figure 1.

Mitochondrial dysfunction in fatty liver. In fatty liver, stressed and damaged mitochondria cause greater oxidative stress and less energy production. New therapeutics that restore mitochondrial function could be a promising way to treat metabolic dysfunction-associated steatotic liver disease. GLP-1, glucagon-like peptide 1; NAD⁺, nicotinamide adenine dinucleotide; NR, nicotinamide riboside; NMN, nicotinamide mononucleotide; MitoQ, mitoquinone; ROS, reactive oxygen species; ATP, adenosine triphosphate.