Table 4.
Sensitivity and Specificity of BioFire PN Panel Results Positive for Any Bacteria vs Clinical Adjudication as the Gold Standard
| No. BioFire Positive | Sensitivity, % | Specificity, % | PPV, % | NPV, % | |
|---|---|---|---|---|---|
| All sputum samples (n = 158) | 95 | 45 | 75 | 84 | |
| Viral (n = 58) | 32 | ||||
| Bacterial (n = 100) | 95 | ||||
| Good quality sputum (n = 122) | 94 | 59 | 84 | 81 | |
| Viral (n = 37) | 15a | ||||
| Bacterial (n = 85) | 80 | ||||
| Moderate quality sputum (n = 36) | 100 | 28 | 59 | 100 | |
| Viral (n = 21) | 17 | ||||
| Bacterial (n = 15) | 15 |
Standard bacteria were detected with or without a virus detected. Clinical adjudication resulted in definitive diagnosis of viral alone or bacterial. Bacterial included bacterial alone and bacterial + viral. Indeterminant cases are not included.
Abbreviations: BioFire PN, BioFire FilmArray Pneumonia Panel; NPV, negative predictive value; PPV, positive predictive value.
a P = .0001. Difference in percentage of BioFire PN–positive samples between bacterial and viral infection.