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. 2023 Dec 22;14:1282996. doi: 10.3389/fimmu.2023.1282996

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Copyright © 2023 Cao, Lai, Liu, Liu, Qin, Tu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ATF5 is upregulated under ER stress and protects cells from ER stress-induced apoptosis. (A) Relative ATF5 mRNA expression in Myla and H9 cells treated for 24h. Relative expression was normalized to GAPDH and vehicle. Relative ATF5 expressions of vehicle groups were normalized as 1 and indicated by the black dashed line. The red dashed box highlights ER stress inducers treatment. (B, C) Specific apoptosis of control (shNC) and ATF5-KD (sh1, sh2) H9 (B) and Myla (C) cells treated with thapsigargin for 48 h. (D, E) Specific apoptosis of control (shNC) and ATF5-KD (sh1, sh2) H9 (D) and Myla (E) cells treated with tunicamycin for 48 h. Data are presented as mean ± SD and representative of at least three independent experiments. ns, no significance, *P<0.05, **P<0.01, ***P<0.001.