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. 2024 Jan 11;8(1):e0359. doi: 10.1097/HC9.0000000000000359

FIGURE 3.

FIGURE 3

HH disease stage–specific immunologic infiltration patterns. (A) Low and high magnification of HE, p16, Vimentin (VIM) and CD4 in non-senescent, p16-senescent and regressed HH. Scale bar: 400 µm (low) and 100 µm (high). (B) Percentual distribution of VIM and CD4 in non-senescent, p16-senescent and regressed HH. Wilcoxon rank-sum test of p16-senescent HH versus HH of interest (***p < 0.001, n.s. = not significant). (C) Heatmaps displaying pairwise correlation metrics of marker-positive cells (%) in non-senescent, p16-senescent and regressed HH center tissues. Spearman correlation coefficient displayed as a color code from 1 (blue) to −1 (red; *p < 0.05, **p < 0.01, ***p < 0.001). (D) Correlation analysis between CD3+/ETS Transcription Factor ERG+ (ERG+) and CD8+/ERG+ percentual numbers in non-senescent HH center cores (Spearman correlation analysis). Abbreviations: HE, hematoxylin eosin; HH, hepatic hemangioma.