Skip to main content
. Author manuscript; available in PMC: 2024 Jan 12.
Published in final edited form as: Curr Opin Chem Biol. 2022 Jul 6;70:102179. doi: 10.1016/j.cbpa.2022.102179

Figure 1. Reported structures of class I HDAC complexes.

Figure 1.

(A) LSD1-CoREST1-HDAC (gold-green-yellow) complex with IP6 (red/orange/dark grey/white), potassium (purple) and zinc (blue). Alphafold-generated HDAC1-RCOR1elm2sant and LSD1-RCOR2linker-sant2 structures were fitted into the EM density map (EMD-10629) and were further refined with Rosetta Relax. (B) MiDEAS-DNTTIP1-HDAC (green-pink-grey) complex with IP6 (red/orange/dark grey/white), potassium (purple) and zinc (blue). (C) NuRD deacetylase module with two each of MTA1 (green), HDAC1 (grey), and RBBP4 (indigo), as well as one MBD2 (gold), and IP6 (red/orange/dark grey/white), potassium (purple) and zinc (blue) (PDBID: 7AOA). (D) SIN3-HDAC1-SAP30L (gold-grey-green/purple) complex with IP6 (red/orange/dark grey/white), potassium (purple) and zinc (blue) (derived from PDBDEV_00000043).