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. 2023 Dec 13;11:rbad108. doi: 10.1093/rb/rbad108

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© The Author(s) 2023. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Safety verification of cur@Exo^CTP. (A) Schematic diagram of in vivo safety assay. (B–E) Serum levels of ALT, AST, BUN and CRE after administration with PBS, free Cur, Exo^CTP and Cur@ExoCTP (n = 5). (F) H&E staining of major organs showing no obvious histological changes after indicated treatments. Scale bar, 100 μm. ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CRE, creatinine. All data are represented as mean ± SD. Two-way ANOVA followed with Tukey’s post hoc test was utilized. ns: not significant.