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. 2024 Jan 16;134(2):e169730. doi: 10.1172/JCI169730

Figure 1. Modeling diabetes during pregnancy.

Figure 1

(A and B) Breeding and treatment schematic used to generate genetic (A) and pharmacological (B) mouse models of GD. (C and D) Dam nonfasting glycemia before, during, and after pregnancy in genetic (C) and pharmacological (D) mouse models (C: n = 17–20/group, D: n = 6–20/group, n = 6–8/group at postweaning age). (E and F) Weaning-age (4 weeks old) and adult-age (8 weeks old) body weight (left panels) and nonfasting glycemia (right panels) of offspring born to diabetic pregnancy in the genetic (E) and pharmacological (F) mouse models (n = 5–8/group). Data are represented as means ± SD. Two-way ANOVA with Šidák’s post hoc test. ***P ≤ 0.0005; ****P ≤ 0.0001.