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. 2024 Jan 16;134(2):e166134. doi: 10.1172/JCI166134

Figure 11. Deletion of Notch3 leads to progressive transcriptional alterations in the neuronal compartment, revealing neurodegeneration.

Figure 11

(A) UMAP plot of scRNA-Seq data from 12-month cortical neurons. (B) Heatmap of the top 30 DEGs in control and Notch3–/– cortical neurons. (C) Network of selected neurodegenerative disease–associated KEGG pathways of cortical neuron DEGs in Notch3–/–. (D) UMAP data from 24-month cortical neurons. (E) Heatmap of the top 30 DEGs in control and Notch3–/– cortical neurons at 24 months. (F) Network visualization of selected neurodegenerative disease–associated KEGG pathways and member genes from the top 20 enriched pathways.