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Half-life (t1/2), intrinsic clearance (CLint), hepatic clearance (CLhep), and hepatic extraction ratio values of fargesin obtained by incubation with human, dog, monkey, mouse, and rat hepatocytes at 37 °C in a CO2 incubator
| Parameters | Human | Dog | Monkey | Mouse | Rat |
|---|---|---|---|---|---|
| t1/2 (min) | 68.3 | 204.0 | 46.2 | 130.6 | 104.2 |
| CLint (mL/min/kg) | 72.5 | 46.7 | 115.2 | 125.4 | 62.3 |
| CLhep (mL/min/kg) | 16.1 | 18.6 | 31.5 | 52.4 | 29.3 |
| Hepatic extraction ratio | 0.78 | 0.60 | 0.73 | 0.58 | 0.53 |
