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. 2023 Aug 2;40(1):23–30. doi: 10.1007/s43188-023-00179-z

Table 2.

Korean microbiological ADI and rationales

ADI 0.01 mg/kg bw/day
Study In vitro microbiological study
Compound Tylosin
Subjects Human gut flora from healthy volunteers
Point of departure (MICcalc) 0.308 μg/mL (MIC50)
Mass of colon content 500 mL
Fraction of oral dose available to microorganisms 0.224
Body weight 60 kg
Reference [9]