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. 2024 Jan 12;7:92. doi: 10.1038/s42003-024-05777-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A FAS catalyzed anabolism of saturated fatty acids from acetyl- and malonyl-CoA using NADPH and FMN as cofactors. B Structure (PDB 6TA1) and domain organization of S. cerevisiae FAS. One α- and β-chain that are integrated within the MPT domain are colored in the 3D model and highlighted in the schematic architecture of FAS to the right. The N- and C-terminus of α- and β-chains, respectively, within the MPT domain are shown as an inset.