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. 2024 Jan 12;15:488. doi: 10.1038/s41467-023-44325-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Effects of mutations in gyrA and gyrB on levofloxacin (pink) and moxifloxacin (green) log2MIC. B Structural mapping of fluoroquinolone resistance-associated variants reveal that majority lie within 10 Å of the drug binding site. Positions gyrB R446 and S447 are not shown. C Effects of mutations in aminoglycoside target genes on amikacin and kanamycin log2MIC. ECOFFs (minus baseline MIC) are shown for comparison. Sample sizes and p values for all effects are provided in Supplementary Data 3.