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. 2024 Jan 12;7:87. doi: 10.1038/s42003-023-05705-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Overlap between interactors in the EC and SMC PPI networks. b Cardiovascular tissue enrichment calculated using GTEx tissue-specific genes based on RNA-seq data. Interactors found exclusively in the EC (EC only) or SMC (SMC only) network and interactors found in both networks (Intersect) were analyzed separately and compared against the rest of the genome. c Gene set enrichment calculated using MSigDB Hallmark gene sets. EC only, SMC only, and Intersect interactors were compared against the non-interactors detected by IP-MS; only the top ten gene sets are shown for each analysis. All P values were calculated using one-tailed hypergeometric tests. For (b, c), nominally (P<0.05) or Bonferroni-significant (P <0.05/number of tissues or gene sets) results are shown in orange or red, respectively; gene counts used for analysis are shown in Supplementary Data 10 and 11.