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. 2024 Jan 12;15:493. doi: 10.1038/s41467-023-43076-7

Fig. 6. Pre- versus posttreatment CD8 + T-cell infiltration and correlation with baseline DLDA scores in group B patients.

Fig. 6

A There was a significant increase in CD8 + T-cell infiltration from baseline tumor samples to day 5 of treatment (CD8: Wilcoxon signed-rank test V = 57, P = 0.032, n = 11). B Development of CD8 + T-cell predominant lymphocytic infiltrates was observed in study patients following one dose of MV treatment, including patients with intermediate DLDA scores. Representative examples of two study patients are shown. C Correlation between DLDA score and CD8 + T-cell increase following treatment. Spearman’s rho = −0.46 (95% CI: −0.83 to 0.19, two-sided P value, P = 0.154, n = 11 patients with available log2 fold change CD8 data). D Lymphocytic cell infiltration was evaluated in tumor specimens obtained in subsequent surgeries following study completion in a subset of study patients; evolution of the percentage of CD8-positive cells is depicted. Source data are provided as Source Data file.