Figure 4.

The effects of A-to-I RNA editing events on protein recoding

A. There are 3785 non-synonymous and 121 stop-loss editing events causing the changes of amino acid sequences. B. 113 A-to-I RNA editing events conferred their deleterious effects on 52 tumor-related proteins assessed by SIFT, Polyphen2, and PROVEAN. Among these, there were 12 proteins with different RNA editing events whose effects were predicted to be diverse by these three tools. C. The Q/R editing in the key YXXQ motif of the BLCAP protein reverses the inhibition ability of BLCAP to STAT3, potentially facilitating the cancer-initiating and progressing events. D. The hypothesis in (C) was supported by its higher editing frequency in breast invasive carcinoma.