Figure 5.

The effects of A-to-I RNA editing events on alternative splicing

A. The distribution of altered splice site strength caused by RNA editing events in the different positions of splicing regions. Individual RNA editing site may belong to different groups according to different exons. B. The analysis procedure for the effects of A-to-I RNA editing events on alternative splicing. C. The intron retention event (IR_105891) was mostly occurred in the RNA-edited group of PCPG. D. The intron retention event (IR_105891) was associated with the frequency of the editing event (CAediting_390714) in PCPG. E. A hypothesis that the R/G editing in GRIA2 may alter the canonical splicing pattern of AG-GU to induce the intron retention for the isoforms of tumor-related GRIA2 in PCPG. 3′-ss, 3′-acceptor splice site; 5′-ss, 5′-donor splice site; PSI, percent spliced in; PCPG, pheochromocytoma and paraganglioma.