Figure 6.

The effects of A-to-I RNA editing events on miRNA regulation

A. RNA editing events in the 3′-UTRs of mRNAs, lncRNAs, and miRNA seed regions led to the changes of miRNA–target interactions. Individual RNA editing site may locate in both of protein-coding or non-coding transcripts due to their possible overlaps. B. The analysis procedure for the effects of A-to-I RNA editing events on miRNA regulation. C. One significant RNA editing event (CAediting_1478179) in the 3′-UTR of APOL1 likely intervened in the miRNA regulation on two TGs (APOL1 and ZNF280D) to play its roles in the UCEC progression. D. The RNA editing event (CAediting_1478179) caused the loss of original miRNA binding target on APOL1. The altered miRNA regulation resulted in the increased expression of APOL1 and indirectly led to the reduced expression of competing ZNF280D gene. E.APOL1 and ZNF280D showed differential expression in UCEC, revealing their potential roles and functions in UCEC. F. Analyses uncovered CAediting_1478179 in the 3′-UTR of APOL1 as a probably pathological biomarker of UCEC. Another significant case shown in panel B is described in Figure S14. UCEC, uterine corpus endometrial carcinoma.