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. 2023 Nov 15;11(2):2305842. doi: 10.1002/advs.202305842

Figure 1.

Figure 1

Osteocyte conditioned media inhibited proliferation and increased migration of breast and prostate cancer cells, with absence of this effect in co‐culture suggesting the existence of a feedback mechanism in vivo. A) Schematic of conditioned media model of early metastasis, and co‐culture model of late metastasis. Fold‐change in B) proliferation, C) migration and D) invasion of breast (MDA‐MD‐231 & MCF‐7) and prostate (PC‐3 & LNCaP) cancer cell lines, after 48 h in conditioned media or co‐culture with the MLO‐Y4 osteocyte‐like cell line (n = 9). Bar charts represent mean ± standard deviation. Statistically significant differences indicated by horizontal lines based on one‐way ANOVA with Bonferroni post‐hoc test (light gray p < 0.05, dark gray p < 0.01, black p < 0.001).