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. 2023 Nov 9;11(2):2302965. doi: 10.1002/advs.202302965

Figure 2.

Figure 2

YAP depletion alters the expression of genes related to membrane organization and endocytosis pathways. A) Heatmap of the relative expression of significantly regulated genes associated with the membrane organization network in YAP ‐/‐ and WT CAL51 cells. n = 4 (P adj < 0.05, log2Fc > ǀ2ǀ). B) STRING PPI network of differently expressed proteins involved in membrane organization in WT (top) and YAP ‐/‐ CAL51 (bottom) cells obtained from Cytoscape (P adj < 0.05, log2Fc > ǀ2ǀ, confidence cutoff 0.4). C) Graphical representation of the main mechanisms of endocytosis, i.e., caveolae‐related endocytosis, clathrin‐related endocytosis, and macropinocytosis, investigated in the present study. D) Heatmap of genes involved in endocytosis pathways for caveolae‐related genes. E) heatmap of genes involved in clathrin‐mediated endocytosis pathways. F). Heatmap of genes involved in macropinocytosis (P adj < 0.05, log2Fc > ǀ1ǀ).