Table 1.

Therapeutic index.

Drug	HIF1α degradation a) (IC50, µM)	Normal cell cytotoxicity b) (IC50, µM)	Therapeutic index (B/A)
MitoQ	0.077 ± 0.016	22.47 ± 0.46	295.81
SB‐U014	0.040 ± 0.091	27.47 ± 0.77	694.92
SB‐U015	0.041 ± 0.083	31.78 ± 0.76	773.05

^a) IC₅₀ values of HIF1α protein degradation in MIO‐M1 cells upon TRAP1 inhibitor treatment were analyzed as in Figure 7A,B (n = 4);

^b) IC₅₀ values of the cytotoxic activities of the drugs in primary Müller cells were calculated as in Figure S18A, Supporting information (n = 4). The therapeutic index^{[ 42 ]} was determined as (IC₅₀ for normal cell cytotoxicity)/(IC₅₀ for HIF1α degradation). Data information: Data are expressed as mean ± SEM.