Table 2.
Ocular pharmacokinetics analysis after topical administration of SB‐U015.
| Mouse | Rabbit | |||||
|---|---|---|---|---|---|---|
| Retina | Retina | Sclera | Aqueous humor | Cornea | Plasma | |
| Cmax [ng/g] | 36.5 ± 7.2 | 65.6 ± 20.1 | 664.3 ± 122.8 | NA | 3272.4 ± 283.7 | NA |
| AUClast [hng/g] | 44.8 ± 6.2 | 90.9 ± 16.9 | 1697.9 ± 318.7 | NA | 9226.6 ± 637.6 | NA |
| Tmax [h] | 0.8 ± 0.2 | 1.5 ± 0.8 | 1.1 ± 0.3 | NA | 2.6 ± 0.9 | NA |
*NA: Not applicable because the analyte was not detected.
Data information: Data are expressed as mean ± SEM (n = 4) except for plasma (n = 2) and mouse retina (n = 3).