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In vivo expression of GOI detected by ligand-receptor binding ELISA
| AAV type | Bioreactor scale | Aflibercept (pg/eye) 28 days post@4E8 |
|---|---|---|
| Sf9-rAAV | 2 L | 118.1 ± 78 |
| HEK-rAAV | 10 L | 135.0 ± 49 |
At 28 days after intravitreal dosing of 4 × 108 vg, transgene expression in the whole eye was measured by ELISA.
