Skip to main content
. 2023 Dec 28;34:237–247. doi: 10.1016/j.bioactmat.2023.12.013

Fig. 5.

Fig. 5

Synergistic effects of VRbp-CNT in combination with Taxol®. (a) Images of mixed primary cultures of lung metastatic tissues treated with ox-MWCNTs (100 μg/mL), Taxol® (TX, 2 μg/mL), and the combination of VRbp-CNT and TX (100 μg/mL and TX, 2 μg/mL each). Cultures treated with nanotubes and chemotherapy exhibit a noticeable reduction in both the number and size of melanoma cell colonies, as indicated by white arrows. (b) Representative images and histological sections of lungs bearing metastases from animals treated with ox-MWCNTs (3 × 100 μg/animal), TX (3 × 2 mg/kg), or both (VRbp-CNT + TX). Significantly fewer melanoma metastases are observed in the lungs (red asterisks) treated with the combination of VRbp-CNT and Taxol®. The scale bars represent 10 and 2 mm, respectively. (c) Quantification shows the percentage of lung parenchyma affected by metastasis, presented as a percentage of the total surface compared to PBS-treated control mice (as a % of the total surface compared to PBS-treated control mice) (n = 52, p = 0 and p = 2.04 E−07 comparing ox-MWCNTs to VRbp-CNT and TX to VRbp-CNT + TX, respectively; ***p < 0.001).