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. 2024 Jan 12;22:48. doi: 10.1186/s12967-024-04860-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — B cells in MIBC. A tSNE plot showing the subclustering of 11,612 B cells from 12 patients with bladder cancer. Each cluster is shown in a different color. Twelve clusters are shown in each plot. B The tSNE map shows the distribution of B-cell characteristic genes CD79A and MS4A1 and plasma cell characteristic genes IGHA1 and MZB1. C Heatmap showing the expression levels of functional markers of B-cell subtypes