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. 2024 Jan 12;22:48. doi: 10.1186/s12967-024-04860-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Interferon-stimulated B cells are enriched in MIBC. A tSNE plots of B cells in MIBC; n = 7; NMIBC, n = 3; normal, n = 9; PBMC, n = 4; lymph nodes, n = 3. Each cluster is shown in a different color. B The bar plots depict the mean cell count of each B-cell subtype in each sample on the left. In the middle, the bar plots illustrate the proportion of each B-cell subtype in each sample. On the right, a box plot displays the proportion of B-ISG15 in each sample.; MIBC, n = 7; NMIBC, n = 3; Normal, n = 9; PBMC, n = 4; lymph nodes, n = 3. C Heatmap shows the GSEA score of a set of hallmark genes enriched in B-cell subtypes. D Heatmap showing the activity of SCENIC transcription factor regulons in each B-cell subtype. E Expression levels of STAT1 and IRF9 marker genes illustrated in tSNE plots in each B-cell subtype. F The violin plots depict the expression patterns of IFN-γ genes, colors as in (A)