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. 2024 Jan 12;22:48. doi: 10.1186/s12967-024-04860-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Germinal center-associated B-cell subtypes present in MIBC. A Heatmap shows GSVA scores of enriched germinal center-associated gene sets. B tSNE plot showing the expression densities of the LMO2, AICDA, and NEIL1 genes in B-cell subtypes. C The Gene Ontology (GO) terms of genes that exhibited significant enrichment in B-LMO2 (top) and B-STMN1 (bottom) were determined through the application of Fisher's test for statistical analysis. D RNA velocity of B-cell subtypes. It shows the transformation of B-cell subtypes. E Box plot showing the proportions of B-LMO2 (left) and B-STMN1 (right) in MIBC, NMIBC, normal tissue, PBMC, and lymph node samples