Figure 1:

This IASP poster of the Gate Control Theory, presented in Adelaide at the 1990 World Congress on Pain, celebrated the 25^th anniversary of the Ronald Melzack and Patrick D. Wall publication: Pain mechanisms: A new theory. Science. 1965;150:971–979. The theory completely changed the way preclinical and clinical pain researchers addressed questions about the generation of acute and chronic pain, and provided important insights into novel approaches to pharmacological, neuromodulatory and psychological methods to pain management.