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. Author manuscript; available in PMC: 2024 Jan 13.
Published in final edited form as: Annu Rev Microbiol. 2023 Apr 27;77:233–253. doi: 10.1146/annurev-micro-032521-013159

Figure 2.

Figure 2

(a) Phylogenetic distribution and synteny of the envelope integrity protein B (eipB) genomic region in Proteobacteria; gene neighborhood is anchored on bamA. Brucella eipB is part of a highly conserved cell envelope gene cluster in the Proteobacteria that includes genes involved in outer membrane protein assembly (bamA), undecaprenyl phosphate biosynthesis, phospholipid synthesis (cdsA), lipopolysaccharide synthesis (lpxDAIB), and translation (ef-ts). eipB (pink) is conserved in the Rhizobiales group of the Alphaproteobacteria (phylogenetic classifications on the right). Skp is present outside the Rhizobiales. Phylogenetic tree is based on BamA protein sequence (left). (b) Crystal structures of Brucella EipB (PDB: 6NTR), Escherichia coli LolB (PDB: 1IWM), E. coli LolA (PDB: 1IWL), and E. coli BamA (PDB: 5OR1). Abbreviation: PDB, Protein Data Bank.