Optical coherence tomography angiography (OCTA) has drastically changed the approach to diagnosis and treatment in ophthalmology.

In this narrative review, the key concepts underlying OCTA technology will be covered, from how to acquire quantitative metrics to OCTA limitations that should be properly considered.

A particular focus on OCTA application in age-related macular degeneration will be undertaken, with an overview of the most recent evidence.

Artificial intelligence and other novel OCTA applications, such as tridimensional visualization, will also be discussed.