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. 2024 Jan 13;14:1244. doi: 10.1038/s41598-024-51715-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The correlation between SNPs within and proximal to the ANRIL sequence and the serum expression of ANRIL (both exon one and exon 19) in premature CAD compared to the non-CAD group. The risk genotype for rs10757274: A>G, rs2383206: A>G, rs2383207: A>G, rs10757278: A>G and rs10738605: C>G is GG, and the risk genotype for rs496892: C>T is TT (A–F). The P- values are regarding one-way ANOVA analyses between all groups and asterisks represent the P-values < 0.05 in multiple comparison analyses. (G, H) ROC curve analysis for rs10738605, rs496892, and the expression of ANRIL. (I) Linkage disequilibrium analysis for the selected SNPs. The name of studied SNPs are at the top of the figure and D’ factor (%) is displayed in the squares below. The empty red squares indicate Dʹ > 0.9. rs10757274, rs2383206, rs2383207 and rs10757278 are in one block and rs496892 and rs10738605 share a block together. (J) The Spearman correlation between all variables. The graph is generated using the Spearman correlation coefficients (r). The scale bar on the right demonstrates the range of the r coefficient in color. The r values close to 1 (blue squares) demonstrate an increasing monotonic pattern between variables and values close to − 1 (red squares) correspond to decreasing monotonic trends between variables. P values ≤ 0.0001 are given ****, while P ≤ 0.001, P ≤ 0.01, and P ≤ 0.05 are given ***, **, and * respectively. ANRIL antisense noncoding RNA in the INK4A locus, CAD Coronary Artery Disease, ROC Receiver Operating Characteristic, BMI body mass index, DBP diastolic blood pressure, FBS fasting blood sugar, HDL-C high-density lipoprotein-cholesterol, LDL-C low-density lipoprotein-cholesterol, SBP systolic blood pressure, T2D Type 2 diabetes, TC total cholesterol.