Table 2.
The distribution of alleles and genotypes of variants.
| Non-CAD (N/%) | CAD (N/%) | OR (95% CI) | P-value | |
|---|---|---|---|---|
| rs10757274 (A>G) | ||||
| Allele frequency | ||||
| A | 62 (40.79) | 72 (39.13) | 1.00 | 0.75 |
| G | 90 (59.21) | 112 (60.78) | 0.93 (0.60–1.43) | |
| Genotypes (Codominant) | ||||
| A/A | 15 (19.74) | 18 (19.57) | 1.00 | |
| A/G | 32 (42.10) | 36 (39.13) | 0.93 (0.40–2.11) | 0.87 |
| G/G | 29 (38.16) | 38 (41.30) | 1.09 (0.46–2.48) | 0.83 |
| Genotypes (Dominant) | ||||
| A/A | 15 (19.74) | 18 (19.57) | 1.00 | |
| A/G–G/G | 61 (80.26) | 74 (80.43) | 1.01 (0.47–2.16) | 0.97 |
| Genotypes (Recessive) | ||||
| A/A–A/G | 47 (61.84) | 54 (58.70) | 1.00 | |
| G/G | 29 (38.16) | 38 (41.30) | 1.14 (0.62–2.10) | 0.67 |
| Genotypes (Over-dominant) | ||||
| A/A–G/G | 44 (57.89) | 56 (60.87) | 1.00 | |
| A/G | 32 (42.11) | 36 (39.13) | 0.88 (0.48–1.61) | 0.70 |
| HWE† |
X2 = 1.25 P = 0.53 |
X2 = 2.93 P = 0.23 |
||
| rs2383206 (A>G) | ||||
| Allele frequency | ||||
| A | 52 (34.21) | 66 (35.87) | 1.00 | 0.75 |
| G | 100 (65.72) | 118 (64.13) | 0.93 (0.59–1.45) | |
| Genotypes (Codominant) | ||||
| A/A | 9 (11.84) | 13 (14.13) | 1.00 | |
| A/G | 34 (44.73) | 40 (43.47) | 0.81 (0.32–2.11) | 0.68 |
| G/G | 33 (43.42) | 39 (42.39) | 0.82 (0.32–2.13) | 0.68 |
| Genotypes (Dominant) | ||||
| A/A | 9 (11.84) | 13 (14.13) | 1.00 | |
| A/G–G/G | 67 (88.16) | 79 (85.87) | 0.82 (0.34–1.93) | 0.66 |
| Genotypes (Recessive) | ||||
| A/A–A/G | 43 (56.58) | 53 (57.61) | 1.00 | |
| G/G | 33 (43.42) | 39 (42.39) | 0.96 (0.53–1.73) | 0.89 |
| Genotypes (Over-dominant) | ||||
| A/A–G/G | 42 (55.26) | 52 (56.52) | 1.00 | |
| A/G | 34 (44.73) | 40 (43.47) | 0.95 (0.52–1.71) | 0.87 |
| HWE |
X2 = 0.002 P = 0.99 |
X2 = 0.28 P = 0.87 |
||
| rs2383207 (A>G) | ||||
| Allele frequency | ||||
| A | 51 (34) | 63 (34.24) | 1.00 | 0.96 |
| G | 99 (66) | 121 (65.76) | 0.98 (0.62–1.56) | |
| Genotypes (Codominant) | ||||
| A/A | 8 (10.66) | 12 (13.04) | 1.00 | |
| A/G | 35 (46.66) | 39 (42.39) | 0.74 (0.26–2.07) | 0.56 |
| G/G | 32 (42.66) | 41 (44.56) | 0.85 (0.30–2.40) | 0.76 |
| Genotypes (Dominant) | ||||
| A/A | 8 (10.66) | 12 (13.04) | 1.00 | |
| A/G–G/G | 67 (89.33) | 80 (86.96) | 0.79 (0.31–2.00) | 0.64 |
| Genotypes (Recessive) | ||||
| A/A–A/G | 43 (57.33) | 51 (55.43) | 1.00 | |
| G/G | 32 (42.66) | 41 (44.56) | 1.08 (0.59–1.96) | 0.80 |
| Genotypes (Over-dominant) | ||||
| A/A–G/G | 40 (53.33) | 53 (57.61) | 1.00 | |
| A/G | 35 (46.67) | 39 (42.39) | 0.84 (0.46–1.52) | 0.58 |
| HWE |
X2 = 0.11 P = 0.94 |
X2 = 0.31 P = 0.85 |
||
| rs496892 (C>T) | ||||
| Allele frequency | ||||
| C | 108 (71.05) | 124 (68.89) | 1.00 | 0.66 |
| T | 44 (28.95) | 56 (31.11) | 1.10 (0.69–1.77) | |
| Genotypes (Codominant) | ||||
| C/C | 38 (50) | 45 (50) | 1.00 | |
| C/T | 32 (42.10) | 34 (37.77) | 0.89 (0.46–1.73) | 0.74 |
| T/T | 6 (7.89) | 11 (12.22) | 1.54 (0.56–4.69) | 0.42 |
| Genotypes (Dominant) | ||||
| C/C | 38 (50) | 45 (50) | 1.00 | |
| C/T–T/T | 38 (50) | 45 (50) | 1.00 (0.54–1.82) | > 0.99 |
| Genotypes (Recessive) | ||||
| C/C–C/T | 70 (92.11) | 79 (87.78) | 1.00 | |
| T/T | 6 (7.89) | 11 (12.22) | 1.62 (0.55–4.62) | 0.35 |
| Genotypes (Over-dominant) | ||||
| C/C–T/T | 44 (57.89) | 56 (62.22) | 1.00 | |
| C/T | 32 (42.10) | 34 (37.77) | 0.83 (0.45–1.53) | 0.57 |
| HWE |
X2 = 0.04 P = 0.97 |
X2 = 1.26 P = 0.53 |
||
| rs10757278 (A>G) | ||||
| Allele frequency | ||||
| A | 67 (45.27) | 79 (43.41) | 1.00 | 0.73 |
| G | 81 (54.73) | 103 (56.59) | 1.07 (0.68–1.68) | |
| Genotypes (Codominant) | ||||
| A/A | 17 (22.97) | 21 (23.07) | 1.00 | |
| A/G | 33 (44.59) | 37 (40.65) | 0.90 (0.42–2.05) | 0.81 |
| G/G | 24 (32.43) | 33 (36.26) | 1.11 (0.49–2.48) | 0.79 |
| Genotypes (Dominant) | ||||
| A/A | 17 (22.97) | 21 (23.07) | 1.00 | |
| A/G–G/G | 57 (77.03) | 70 (76.92) | 0.99 (0.48–2.02) | 0.98 |
| Genotypes (Recessive) | ||||
| A/A–A/G | 50 (67.57) | 58 (63.74) | 1.00 | |
| G/G | 24 (32.43) | 33 (36.26) | 1.18 (0.62–2.23) | 0.60 |
| Genotypes (Over-dominant) | ||||
| A/A–G/G | 41 (55.41) | 54 (59.34) | 1.00 | |
| A/G | 33 (44.59) | 37 (40.65) | 0.85 (0.46–1.55) | 0.61 |
| HWE |
X2 = 0.74 P = 0.69 |
X2 = 2.70 P = 0.25 |
||
| rs10738605 (C>G) | ||||
| Allele frequency | ||||
| C | 46 (31.08) | 59 (33.15) | 1.00 | 0.69 |
| G | 102 (68.92) | 119 (66.85) | 0.90 (0.57–1.47) | |
| Genotypes (Codominant) | ||||
| C/C | 6 (8.10) | 13 (14.60) | 1.00 | |
| C/G | 34 (45.94) | 33 (37.07) | 0.44 (0.14–1.36) | 0.13 |
| G/G | 34 (45.94) | 43 (48.31) | 0.58 (0.19–1.73) | 0.31 |
| Genotypes (Dominant) | ||||
| C/C | 6 (8.10) | 13 (14.60) | 1.00 | |
| C/G–G/G | 68 (91.89) | 76 (85.39) | 0.51 (0.18–1.38) | 0.19 |
| Genotypes (Recessive) | ||||
| C/C–C/G | 40 (54.05) | 46 (51.69) | 1.00 | |
| G/G | 34 (45.94) | 43 (48.31) | 1.10 (0.60–2.00) | 0.76 |
| Genotypes (Over-dominant) | ||||
| C/C–G/G | 40 (54.05) | 56 (62.92) | 1.00 | |
| C/G | 34 (45.94) | 33 (37.07) | 0.69 (0.37–1.28) | 0.25 |
| HWE |
X2 = 0.38 P = 0.82 |
X2 = 2.37 P = 0.30 |
||
The frequency of alleles and genotypes of rs10757274, rs2383206, rs2383207, rs496892, rs10757278, and rs10738605 in CAD and non-CAD groups are listed. The odd ratios and P-values are outputs of χ2 tests. For Hardy–Weinberg Equilibrium, χ2 values are also included in the table.
†Hardy–Weinberg Equilibrium.