Fig. 6. Entosis in patient tumors correlates with invasive features.

A Representative entotic cells in HCC tumor tissues stained with DAPI (Blue) and pan-keratin/bate-catenin (Green). Scale bar, 50 µm. B HCC tissues stained using hematoxylin staining, and Rnd3 antibody. Scale bar: 2.5 mm. Entotic cells were evaluated in the positive (red) or negative (gray) Rnd3 areas. Scale bar: 50 µm. C Correlation between the number of entotic cells and the presence (Yes) or not (No) of satellite nodules or vascular invasion. N = 10 patient samples, significance was determined with the Mann–Whitney U-test.