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. 2024 Jan 13;15(1):45. doi: 10.1038/s41419-023-06416-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Gene expression profile of IGFBP4 in TCGA/CGGA glioma datasets stratified by tumor grade. B Gene expression analysis of IFITM3 in GBM (TCGA) and normal brain tissues (GTEx) was conducted using GEPIA2 web tool. C Kaplan–Meier survival analysis of GBM/LGG patients with high or low IFITM3 expression. D Representative images of IHC staining for IFITM3 in patients with high or low-grade glioma from Human Protein Atlas datasets. E Representative IHC images for IFITM3 in patients diagnosed as grade IV or Grade II glioma from Zhujiang Hospital. F IHC score of IFITM3 in human glioma samples stratified by tumor grade. G Correlation of IFITM3 expression with gender, age, tumor size, and tumor grade. Scale bar = 25/50 μm. Data are expressed as Mean ± SD. **p < 0.05, **p < 0.01, ***p < 0.001. TCGA The Cancer Genome Atlas, CGGA Chinese Glioma Genome Atlas, GBM Glioblastoma, LGG Low-grade gliomas, IHC Immunohistochemistry.