Table 3.
In utilization cohort: multivariable logistic regression analyzing the association between receipt of NAC and clinical factors among patients with breast cancer (BCBaSe 3.0/NKBC, 2008–2019)
| OR | 95% CI | 95% CI | P-value | |
|---|---|---|---|---|
| Low | High | |||
| Female versus male | 1.135 | 0.606 | 2.128 | 0.692 |
| Age | 0.967 | 0.963 | 0.970 | < 0.001 |
| Educational Level | ||||
| High (≧13 years) | Ref | |||
| Intermediate (10–12 years) | 0.732 | 0.628 | 0.853 | < 0.001 |
| Low (≦9 years) | 0.890 | 0.801 | 0.989 | 0.030 |
| Household Income | ||||
| Q4 (High) | Ref | |||
| Q3 | 0.708 | 0.624 | 0.803 | < 0.001 |
| Q2 | 0.676 | 0.591 | 0.773 | < 0.001 |
| Q1 (Low) | 0.585 | 0.504 | 0.680 | < 0.001 |
| Healtcare regions | ||||
| Northern | Ref | |||
| Stockholm Gotland | 2.707 | 2.197 | 3.335 | < 0.001 |
| Uppsala-Örebro | 0.826 | 0.657 | 1.038 | 0.101 |
| South | 2.119 | 1.698 | 2.645 | < 0.001 |
| Southeast | 1.664 | 1.313 | 2.108 | < 0.001 |
| Western | 0.813 | 0.647 | 1.023 | 0.077 |
| Clinical T stage | ||||
| T1-2 | Ref | |||
| T3-4 | 4.151 | 1.782 | 9.667 | < 0.001 |
| Clinical N stage | ||||
| cN- | Ref | |||
| cN + | 1.888 | 1.039 | 3.432 | 0.037 |
| Histological grade | ||||
| I | Ref | |||
| II | 4.305 | 3.587 | 5.167 | < 0.001 |
| III | 4.049 | 3.575 | 4.586 | < 0.001 |
| Subtype according to IHC | ||||
| Luminal | Ref | |||
| HER2-positive | 3.077 | 2.714 | 3.489 | < 0.001 |
| Triple-negative | 5.876 | 5.077 | 6.802 | < 0.001 |
| Morphological type | ||||
| Ductal | Ref | |||
| Lobular | 0.778 | 0.669 | 0.906 | < 0.001 |
| Other | 0.667 | 0.530 | 0.838 | < 0.001 |
The multivariate models were complete case analyses
Bold text indicates a statistically significant difference with a p-value less than 0.05